Table 1. Scores for the top 59 mutants from genome-wide screen.

ORF	Gene Name	Screen 1	Screen 2	Average Score	Genome Stabilitya
GOS1	YHL031C	0.12	0.24	0.18
SMI1	YGR229C	0.31	0.42	0.37
SRB2	YHR041C	0.41	0.41	0.41	+
BUB1	YGR188C	0.21	0.19	0.20	+
FBP26	YJL155C	0.09	0.24	0.17	+
MPH1	YIR002C	0.21	0.26	0.24	+
POL32	YJR043C	0.24	0.28	0.26	+
LAS21	YJL062W	0.32	0.41	0.36
SWF1	YDR126W	0.00	0.03	0.02
TOP3	YLR234W	0.34	0.21	0.27	+
VPS53	YJL029C	0.11	0.17	0.14	+
UBP3	YER151C	0.39	0.24	0.32	+
YDR455C	YDR455C	0.31	0.28	0.30
HHY1	YEL059W	0.29	0.33	0.31
RAD51	YER095W	0.15	0.45	0.30	+
BST1	YFL025C	0.28	0.50	0.39
SPF1	YEL031W	0.33	0.47	0.40
RPO41	YFL036W	0.39	0.43	0.41
RPL19B	YBL027W	0.26	0.20	0.23
MRC1	YCL061C	0.37	0.19	0.28
SLX5	YDL013W	0.37	0.36	0.37	+
PER1	YCR044C	0.19	0.46	0.32	+
RIC1	YLR039C	0.33	0.23	0.28
SWI6	YLR182W	0.20	0.33	0.27
YJL175W	YJL175W	0.18	0.49	0.33
BUB3	YOR026W	0.10	0.17	0.13
DIA2	YOR080W	0.32	0.36	0.34	+
PAP2	YOL115W	0.27	0.32	0.29	+
VAM3	YOR106W	0.20	0.35	0.27
VAM10	YOR068C	0.17	0.42	0.30
SHE4	YOR035C	0.25	0.40	0.32
TLG2	YOL018C	0.41	0.49	0.45
YPT6	YLR262C	0.22	0.17	0.20
ARC1	YGL105W	0.18	0.29	0.24
COG8	YML071C	0.19	0.20	0.20	+
YMR031W-A	YMR031W-A	0.13	0.08	0.10
YNL171C	YNL171C	0.37	0.21	0.29
YMR166C	YMR166C	0.14	0.48	0.31
COG6	YNL041C	0.20	0.30	0.25
SAC1	YKL212W	0.00	0.05	0.02
CPS1	YJL172W	0.33	0.50	0.41
RPE1	YJL121C	0.07	0.27	0.17
HTZ1	YOL012C	0.41	0.48	0.44
JHD2	YJR119C	0.31	0.32	0.32	+
DPB3	YBR278W	0.41	0.42	0.41
EAF1	YDR359C	0.29	0.13	0.21	+
MNN10	YDR245W	0.12	0.13	0.13	+
PPH3	YDR075W	0.31	0.19	0.25
SPT3	YDR392W	0.05	0.34	0.20	+
SWI4	YER111C	0.19	0.18	0.19
SNX4	YJL036W	0.29	0.24	0.26	+
ASC1	YMR116C	0.14	0.21	0.17
COG7	YGL005C	0.14	0.28	0.21	+
VAM7	YGL212W	0.00	0.21	0.11
DBF2	YGR092W	0.12	0.46	0.29	+
CKB1	YGL019W	0.27	0.47	0.37
LEA1	YPL213W	0.40	0.24	0.32
VPS1	YKR001C	0.00	0.00	0.00
ERG3	YLR056W	0.38	0.27	0.33

^aGenome stability (+) indicates that the respective gene has been reported to have function(s) in pathway(s) important for maintaining genome integrity.