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. 2016 Feb 1;27(3):518–534. doi: 10.1091/mbc.E15-07-0504

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© 2016 Williams et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 3: — Increased cortical neuron nascent axon length, total neurite length, and neurite number due to increased GAP-43 protein expression upon hnRNP-Q1 knockdown. (A) Average nascent axon length, (B) total neurite length, and (C) neurite number of selected neurons from Figure 2 were quantified. n = 7, Scr + Scr: 62 out of 173 cells; Scr + GAP-43: 59 out of 181 cells; Q1 + Scr: 47 out of 170 cells; and Q1 + GAP-43: 145 out of 184 cells from seven independent experiments. One-way ANOVA, Tukey’s posthoc, nascent axon length p values: Scr + Scr vs. Scr + GAP-43, p = 0.8423; Scr + Scr vs. Q1 + Scr, p = 0.0004; Scr + Scr vs. Q1 + GAP-43, p = 0.5784; Scr + GAP-43 vs. Q1 + Scr, p < 0.0001; Scr + GAP-43 vs. Q1 + GAP-43, p = 0.9921; Q1 + Scr vs. Q1 + GAP-43, p < 0.0001; total neurite length p values: Scr + Scr vs. Scr + GAP-43, p = 0.9884; Scr + Scr vs. Q1 + Scr, p < 0.0001; Scr + Scr vs. Q1 + GAP-43, p = 0.2956; Scr + GAP-43 vs. Q1 + Scr, p < 0.0001; Scr + GAP-43 vs. Q1 + GAP-43, p = 0.5334; Q1 + Scr vs. Q1 + GAP-43, p < 0.0001; neurite number p values: Scr + Scr vs. Scr + GAP-43, p = 0.9707; Scr + Scr vs. Q1 + Scr, p = 0.0021; Scr + Scr vs. Q1 + GAP-43, p = 0.4028; Scr + GAP-43 vs. Q1 + Scr, p = 0.0098; Scr + GAP-43 vs. Q1 + GAP-43, p = 0.1699; Q1 + Scr vs. Q1 + GAP-43, p < 0.0001. (D–F) Cumulative distribution plots for each measurement of selected neurons from Figure 2.