FIGURE 11:

Distribution of microtubule-coating proteins in apicomplexan parasites and their photosynthetic relatives. The presence (filled circle) or absence (open circle) of predicted homologues for proteins associated with the cortical microtubules in T. gondii in representative members of the phylum Apicomplexa with available genome sequences and its two photosynthetic relatives, C. velia and Vitrella brassicaformis. Gray circles, predicted proteins whose sequence appears truncated or duplicated due to incomplete assembly. Full-length T. gondii homologues were used for the initial BLAST search against the predicted protein databases (eupathdb.org/eupathdb/). E-value cut-off, 0.005. For TLAP3 and SPM2, several divergent Plasmodium homologues were not captured in the initial BLAST search but were confirmed by using the sequences for more conserved Plasmodium homologues as the query. For TrxL1 and TrxL2, due to the conserved nature of the thioredoxin-like fold, only hits with E-value <1e-18 were considered, and hits with E-value between 1e-30 and 1e-18 were manually curated to classify as TrxL1 or TrxL2 homologues.