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. 2016 Feb 12;16:5. doi: 10.1186/s12935-016-0283-8

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© Deng et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Melatonin promotes apoptosis of SGC-7901 gastric cancer cells. SGC-7901 cells were incubated with melatonin for the indicated doses and periods. a The morphological figures of apoptosis were monitored by fluorescence microscopy after staining with Hoechst 33258. Images are representative of at least three independent determinations. Scale bar 50 μm. b Melatonin-induced apoptosis of SGC-7901 gastric cancer cells. Values were presented as mean ± SD of three independent experiments. c Cell proliferation was measured by MTT assay. d Apoptosis was evaluated for up to 48 h by Hoechst 33258 staining. Images are representative of at least three independent determinations. Scale bar 50 μm. **P < 0.01