Table 1.
Effects of RU-complexes on growth of various human cancer cells
| Cell linea | EC50(µM)b | |
|---|---|---|
| o-PDA | o-BQDI | |
| HCC38 (breast ca. TN) | >260 | >260 |
| HCC1806 (breast ca. TN) | >260 | >260 |
| MCF-7 (breast ca. LA) | 50 | >260 |
| SUM149 (breast ca. TN) | 150 | >260 |
| HT1080 (osteosarcoma) | 130 | >260 |
| Raji (lymphoma) | 160 | >260 |
| Bowes (melanoma) | 110 | >260 |
| SK-Br-3 (breast ca. Her2+) | 50 | >260 |
TN triple-negative, LA luminal A
aCells (2 × 105 cells/well) were treated serially diluted o-PDA or o-BQDI for 48 h. Cell growth was evaluated by colorimetric assays using WST-1 as an indicator. Experiments were repeated three times
bEC50 was calculated from three independent experiments. Standard error was less than 5 % of mean