FIG 2.

DUBs that regulate replication-associated repair (A), nucleotide excision repair (B), and alkylation adducts repair (C).?^a indicates that both proteolytic and nonproteolytic ubiquitination are reported. RNF111 induces K63-linked polyubiquitin chains on SUMO-modified XPC (not shown). RNF111 and CUL4-DDB2 possibly have opposing roles in the chromatin recruitment of XPC but collaboratively regulate the timely recruitment and removal of XPC at the lesions. As USP7 is not known to cleave K63 linkages, there may be more than one deubiquitinating enzymes involved.