Table 3.
Correlation between clinical data and DTCs, CTCs, and slCTCs before therapy
Total | DTC-positive, n (%) | p Value | Total | CTC-positive, n (%) | p Value | Total | slCTC-positive (%) | p Value | |
---|---|---|---|---|---|---|---|---|---|
Tumor size | 139 | 37 (27) | 132 | 31 (23) | 89 | 44 (49) | |||
cT1 | 32 | 5 (16) | 0.27 | 32 | 10 (31) | 0.26 | 26 | 15 (58) | 0.56 |
cT2 | 86 | 25 (29) | 81 | 19 (23) | 53 | 25 (47) | |||
Above cT2 | 21 | 7 (33) | 19 | 2 (11) | 10 | 4 (40) | |||
Nodal status | 141 | 38 (27) | 134 | 32 (24) | 90 | 45 (50) | |||
cN0 | 77 | 28 (36) | 0.03 | 74 | 21 (28) | 0.62 | 46 | 24 (52) | 0.44 |
cN1 | 56 | 9 (16) | 53 | 11 (21) | 39 | 20 (51) | |||
cN2, cN3 | 8 | 1 (13) | 7 | 0 (0) | 5 | 1 (20) | |||
Histology | 140 | 37 (26) | 133 | 32 (24) | 90 | 45 (50) | |||
Ductal | 106 | 27 (25) | 0.046 | 99 | 22 (22) | 0.70 | 67 | 33 (49) | 0.80 |
Lobular | 16 | 8 (50) | 17 | 5 (29) | 12 | 7 (58) | |||
Others | 18 | 2 (11) | 17 | 5 (29) | 11 | 5 (45) | |||
Grade | 139 | 38 (27) | 132 | 32 (24) | 89 | 44 (49) | |||
I | 9 | 2 (22) | 0.87 | 12 | 0 (0) | 0.31 | 5 | 3 (60) | |
II | 65 | 19 (29) | 59 | 12 (20) | 40 | 17 (43) | 0.49 | ||
III | 65 | 17 (26) | 61 | 20 (33) | 44 | 24 (55) | |||
ER status | 141 | 38 (27) | 134 | 32 (24) | 90 | 45 (50) | |||
Negative | 43 | 8 (17) | 0.14 | 41 | 8 (20) | 0.43 | 24 | 11 (46) | 0.63 |
Positive | 98 | 30 (31) | 93 | 24 (26) | 66 | 34 (52) | |||
PR status | 141 | 38 (27) | 134 | 32 (24) | 90 | 45 (50) | |||
Negative | 60 | 14 (23) | 0.41 | 56 | 13 (23) | 0.88 | 39 | 19 (49) | 0.83 |
Positive | 81 | 24 (30) | 78 | 19 (24) | 51 | 26 (51) |
CTC circulating tumor cell, DTC disseminated tumor cell, ER estrogen receptor, PR progesterone receptor, slCTC stem cell–like circulating tumor cell