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Change from baseline in MADRS total score (A) and BPI-SF average pain score. (B) Effect size is the LS mean estimate divided by the square root of the residual variance (*P ≤ 0.01; **P ≤ 0.001 MMRM). BPI-SF, Brief Pain Inventory-Short Form; LS mean, least-squares mean; MADRS, Montgomery–Åsberg Depression Rating Scale; MMRM, mixed-effects model repeated-measures.
