Table 6.
Gene Upregulation After DEP Exposure in Cultured Human Airway Epithelial Cells
| Probe Set ID | Unigene IDa |
Gene Symbol |
Gene Title | Fold (log)b | |
|---|---|---|---|---|---|
| 10 µg/cm2 | 40 µg/cm2 | ||||
| 202437_s_at | Hs.154654 | CYP1B1 | Cytochrome P450 | 1.00 | 1.22 |
| 202435_s_at | Hs.154654 | CYP1B1 | Cytochrome P450 | 1.00 | 1.19 |
| 205749_at | Hs.72912 | CYP1A1 | Cytochrome P450 | 1.00 | 1.29 |
| 202436_s_at | Hs.154654 | CYP1B1 | Cytochrome P450 | 1.00 | 1.21 |
| 202393_s_at | Hs.435001 | KLF10 | Kruppel-like factor 10 | 1.05 | 1.51 |
| 208937_s_at | Hs.504609 | ID1 | Inhibitor of DNA binding 1 | 1.08 | 1.47 |
| 208892_s_at | Hs.298654 | DUSP6 | Dual specificity phosphatase 6 | 1.15 | 1.29 |
| 202241_at | Hs.444947 | TRIB1 | Tribbles homolog 1 (Drosophila) | 1.19 | 1.56 |
| 201631_s_at | Hs.591785 | IER3 | Immediate early response 3 | 1.13 | 1.30 |
| 222168_at | Hs.675520 | 10q21 mRNA sequence | 1.46 | 1.59 | |
| 208891_at | Hs.298654 | DUSP6 | Dual specificity phosphatase 6 | 1.18 | 1.41 |
| 225133_at | Hs.298658 | KLF3 | Kruppel-like factor 3 (basic) | 1.25 | 1.38 |
| 234608_at | Hs.436367 | LAMA3 | Laminin | 1.36 | 1.85 |
| 202859_x_at | Hs.624 | IL8 | Interleukin 8 | 1.12 | 1.42 |
| 233413_at | Hs.210390 | CDNA FLJ13457 fis | 1.06 | 1.38 | |
| 231578_at | Hs.62661 | GBP1 | Guanylate binding protein 1 | 0.48 | 1.13 |
| 213848_at | Hs.595184 | MRNA; cDNA DKFZp586F2224 | 1.09 | 1.27 | |
| 227335_at | Hs.517172 | DIDO1 | Death inducer-obliterator 1 | 1.00 | 1.73 |
| 238909_at | Hs.143873 | S100A10 | S100 calcium binding protein A10 | 1.00 | 1.29 |
| 235803_at | Hs.658293 | Transcribed locus | 1.22 | 1.40 | |
| 208893_s_at | Hs.298654 | DUSP6 | Dual specificity phosphatase 6 | 1.24 | 1.32 |
| 232947_at | Hs.661499 | CDNA FLJ11476 fis | 1.05 | 1.49 | |
| 202768_at | Hs.590958 | FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.98 | 2.20 |
| 202581_at | Hs.274402 | HSPA1B | Heat shock 70kDa protein 1B | 1.00 | 1.58 |
| 228280_at | Hs.512833 | ZC3HAV1L | Zinc finger CCCH-type | 1.21 | 1.43 |
| 203394_s_at | Hs.250666 | HES1 | Hairy and enhancer of split 1 | 0.99 | 1.50 |
| 213680_at | KRT6B | Keratin 6B | 1.12 | 1.57 | |
| 204014_at | Hs.417962 | DUSP4 | Dual specificity phosphatase 4 | 1.44 | 1.35 |
| 232164_s_at | Hs.200412 | EPPK1 | Epiplakin 1 | 1.38 | 1.46 |
| 212665_at | Hs.12813 | TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 1.21 | 1.19 |
| 214696_at | Hs.597755 | C17orf91 | Chromosome 17 open reading frame 91 | 1.07 | 1.71 |
| 1558220_at | Hs.599259 | MUC20 | Mucin 20 | 1.12 | 1.32 |
| 213765_at | Hs.512842 | MFAP5 | Microfibrillar associated protein 5 | 1.23 | 1.22 |
| 205207_at | Hs.654458 | IL6 | Interleukin 6 (interferon) | 1.19 | 1.40 |
| 227280_s_at | Hs.471234 | CCNYL1 | Cyclin Y-like 1 | 1.22 | 1.33 |
| 212099_at | Hs.502876 | RHOB | Ras homolog gene family | 1.00 | 1.72 |
| 235629_at | Hs.658355 | Transcribed locus | 1.36 | 1.15 | |
| 200769_s_at | Hs.516157 | MAT2A | Methionine adenosyltransferase II | 1.00 | 1.35 |
| 227697_at | Hs.527973 | SOCS3 | Suppressor of cytokine signaling 3 | 1.29 | 1.10 |
| 227949_at | Hs.473218 | PHACTR3 | Phosphatase and actin regulator 3 | 1.03 | 1.38 |
| 203395_s_at | Hs.250666 | HES1 | Hairy and enhancer of split 1 | 1.02 | 1.51 |
| 242471_at | Hs.191475 | Clone HLS_IMAGE_238756 mRNA sequence | 1.21 | 1.13 | |
| 232174_at | Hs.655763 | CDNA: FLJ21635 fis | 1.43 | 1.12 | |
| 218559_s_at | Hs.702085 | MAFB | v-maf Musculoaponeurotic fibrosarcoma oncogene | 1.06 | 1.82 |
| 205476_at | Hs.75498 | CCL20 | Chemokine (C-C motif) ligand 20 | 1.49 | 1.12 |
| 228955_at | Hs.280387 | Transcribed locus | 1.28 | 1.40 | |
| 216997_x_at | Hs.444213 | TLE4 | Transducin-like enhancer of split 4 | 1.18 | 1.07 |
| 211506_s_at | Hs.624 | IL8 | Interleukin 8 | 1.31 | 1.51 |
| 204614_at | Hs.594481 | SERPINB2 | Serpin peptidase inhibitor | 1.58 | 1.28 |
| 226734_at | Hs.292026 | EIF4E2 | Eukaryotic translation initiation factor 4E-2 | 1.00 | 1.46 |
| 223441_at | Hs.597422 | SLC17A5 | Solute carrier family 17 (anion/sugar transporter) | 1.15 | 1.09 |
| 209774_x_at | Hs.590921 | CXCL2 | Chemokine (C-X-C motif) ligand 2 | 1.40 | 1.43 |
| 1557094_at | Hs.463110 | LOC653110 | Hypothetical LOC653110 | 1.00 | 1.73 |
| 232181_at | Hs.483816 | LOC153346 | Hypothetical protein LOC153346 | 1.32 | 1.32 |
| 209684_at | Hs.472270 | RIN2 | Ras and Rab interactor 2 | 1.08 | 1.45 |
| 212993_at | Hs.531457 | MRNA; cDNA DKFZp667B1718 | 1.00 | 1.77 | |
| 221840_at | Hs.127022 | PTPRE | Protein tyrosine phosphatase | 1.16 | 1.35 |
| 205064_at | Hs.1076 | SPRR1B | Small proline-rich protein 1B (cornifin) | 1.02 | 1.16 |
| 234594_at | Hs.612888 | C14orf85 | Chromosome 14 open reading frame 85 | 1.24 | 1.28 |
| 212660_at | Hs.483419 | PHF15 | PHD finger protein 15 | 1.00 | 1.65 |
| 208712_at | Hs.523852 | CCND1 | Cyclin D1 | 1.00 | 1.51 |
| 212200_at | Hs.654628 | KIAA0692 | KIAA0692 | 1.26 | 1.23 |
| 226982_at | Hs.592742 | ELL2 | Elongation factor | 1.39 | 1.17 |
| 232165_at | Hs.200412 | EPPK1 | Epiplakin 1 | 1.40 | 1.55 |
| 201466_s_at | Hs.525704 | JUN | Jun oncogene | 1.22 | 1.63 |
| 226860_at | Hs.688627 | TMEM19 | Transmembrane protein 19 | 1.16 | 1.46 |
| 244354_at | Hs.128434 | ELISC-1 | 1.12 | 1.30 | |
| 241950_at | Hs.680156 | Transcribed locus | 1.07 | 1.24 | |
| 230653_at | Hs.671710 | LOC728555 | Hypothetical protein LOC728555 | 1.13 | 1.48 |
| 244447_at | Hs.666767 | Transcribed locus | 1.13 | 1.24 | |
| 205463_s_at | Hs.705381 | PDGFA | Platelet-derived growth factor alpha polypeptide | 1.00 | 1.54 |
| 39248_at | Hs.234642 | AQP3 | Aquaporin 3 (Gill blood group) | 1.16 | 1.57 |
| 243431_at | Hs.674461 | Transcribed locus | 1.13 | 1.54 | |
| 219016_at | FASTKD5 | FAST kinase domains 5 | 1.01 | 1.69 | |
| 232541_at | Hs.664233 | CDNA FLJ20099 fis | 1.18 | 1.24 | |
| 202936_s_at | Hs.700579 | SOX9 | SRY (sex determining region Y)-box 9 | 0.96 | 1.46 |
| 238477_at | Hs.634167 | CDNA clone IMAGE:4830091 | 1.00 | 1.52 | |
| 209189_at | Hs.25647 | FOS | v-fos FBJ murine osteosarcoma viral oncogene homolog | 1.00 | 1.58 |
| 227140_at | Hs.28792 | CDNA FLJ11041 fis | 1.73 | 1.50 | |
| 202016_at | Hs.270978 | MEST | Mesoderm specific transcript homolog (mouse) | 1.19 | 1.58 |
| 229126_at | Hs.688627 | TMEM19 | Transmembrane protein 19 | 1.10 | 1.30 |
| 221768_at | Hs.355934 | SFPQ | Splicing factor proline/glutamine-rich | 1.13 | 1.27 |
| 226974_at | Hs.594057 | cDNA clone CS0DF038YD07 of Fetal brain | 1.36 | 1.39 | |
| 213051_at | Hs.133512 | ZC3HAV1 | Zinc finger CCCH-type | 1.06 | 1.42 |
| 212239_at | Hs.132225 | PIK3R1 | Phosphoinositide-3-kinase | 1.15 | 1.24 |
| 227034_at | Hs.355455 | ANKRD57 | Ankyrin repeat domain 57 | 1.15 | 1.47 |
| 212168_at | RBM12 | RNA binding motif protein 12 | 1.00 | 1.49 | |
| 200768_s_at | Hs.516157 | MAT2A | Methionine adenosyltransferase II | 1.00 | 1.37 |
| 232235_at | Hs.124673 | DSEL | Dermatan sulfate epimerase-like | 1.18 | 1.59 |
| 223159_s_at | Hs.197071 | NEK6 | NIMA (never in mitosis gene a)-related kinase 6 | 1.01 | 1.35 |
| 229549_at | Hs.592258 | Transcribed locus | 1.06 | 1.34 | |
| 225262_at | Hs.220971 | FOSL2 | FOS-like antigen 2 | 1.00 | 1.55 |
| 208691_at | Hs.529618 | TFRC | Transferrin receptor (p90) | 1.01 | 1.57 |
| 204326_x_at | Hs.374950 | MT1X | Metallothionein 1X | 1.00 | 1.32 |
| 1554250_s_at | Hs.661254 | TRIM73 | Tripartite motif-containing 73 | 1.22 | 1.62 |
| 221215_s_at | Hs.517310 | RIPK4 | Receptor-interacting serine-threonine kinase 4 | 0.84 | 1.79 |
| 227964_at | Hs.578433 | FRMD8 | FERM domain containing 8 | 1.20 | 1.38 |
| 226360_at | Hs.655242 | ZNRF3 | Zinc and ring finger 3 | 1.28 | 1.49 |
| 204470_at | Hs.789 | CXCL1 | Chemokine (C-X-C motif) ligand 1 | 1.45 | 1.40 |
| 223474_at | Hs.179260 | C14orf4 | Chromosome 14 open reading frame 4 | 1.00 | 1.49 |
| 211538_s_at | Hs.432648 | HSPA2 | Heat shock 70kDa protein 2 | 1.00 | 1.95 |
| 223218_s_at | Hs.319171 | NFKBIZ | Nuclear factor of kappa light polypeptide gene enhancer | 1.43 | 1.31 |
| 219476_at | Hs.32417 | C1orf116 | Chromosome 1 open reading frame 116 | 1.21 | 1.88 |
| 225601_at | Hs.693708 | HMGB3 | High-mobility group box 3 | 1.19 | 1.37 |
| 213139_at | Hs.360174 | SNAI2 | Snail homolog 2 (Drosophila) | 1.17 | 1.38 |
| 229830_at | Hs.535898 | Transcribed locus | 1.00 | 1.44 | |
| 238431_at | Hs.593044 | Transcribed locus | 1.29 | 1.39 | |
| 225634_at | Hs.133512 | ZC3HAV1 | Zinc finger CCCH-type | 1.00 | 1.81 |
| 202935_s_at | Hs.700579 | SOX9 | SRY (sex determining region Y)-box 9 | 0.94 | 1.38 |
| 201465_s_at | Hs.525704 | JUN | Jun oncogene | 1.14 | 1.64 |
| 242434_at | Hs.529514 | CDNA FLJ31093 fis | 1.08 | 1.51 | |
| 239448_at | Hs.658524 | Transcribed locus | 1.33 | 1.81 | |
| 209446_s_at | C7orf44 | Chromosome 7 open reading frame 44 | 1.04 | 1.40 | |
| 222243_s_at | Hs.474978 | TOB2 | Transducer of ERBB2 | 1.21 | 1.39 |
| 200799_at | Hs.520028 | HSPA1A | Heat shock 70kDa protein 1A | 1.00 | 2.02 |
| 229492_at | Hs.515130 | VANGL1 | Vang-like 1 (van gogh) | 1.04 | 1.57 |
| 211985_s_at | Hs.282410 | CALM1 | Calmodulin 1 (phosphorylase kinase) | 1.00 | 1.86 |
| 228977_at | Hs.130652 | LOC729680 | Hypothetical protein LOC729680 | 1.11 | 1.44 |
| 208161_s_at | Hs.463421 | ABCC3 | ATP-binding cassette | 1.00 | 1.44 |
| 209360_s_at | Hs.149261 | RUNX1 | Runt-related transcription factor 1 | 1.01 | 1.55 |
| 218051_s_at | Hs.84753 | NT5DC2 | 5'-Nucleotidase domain containing 2 | 1.00 | 2.04 |
| 223217_s_at | Hs.319171 | NFKBIZ | Nuclear factor of kappa light polypeptide gene enhancer | 1.38 | 1.49 |
| 233506_at | Hs.102941 | Full length insert cDNA clone ZB81B12 | 1.17 | 1.53 | |
| 226632_at | Hs.95120 | CYGB | Cytoglobin | 1.00 | 1.67 |
| 222450_at | Hs.517155 | TMEPAI | Transmembrane | 1.00 | 2.58 |
| 209260_at | Hs.523718 | SFN | Stratifin | 1.00 | 1.69 |
| 235086_at | Hs.164226 | THBS1 | Thrombospondin 1 | 1.47 | 2.40 |
| 205027_s_at | Hs.432453 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | 1.68 | 1.85 |
| 201150_s_at | Hs.701968 | TIMP3 | TIMP metallopeptidase inhibitor 3 | 1.00 | 1.76 |
| 200880_at | Hs.445203 | DNAJA1 | DnaJ (Hsp40) homolog | 1.00 | 1.66 |
| 234730_s_at | Hs.517310 | RIPK4 | Receptor-interacting serine-threonine kinase 4 | 1.13 | 2.04 |
| 219371_s_at | Hs.107740 | KLF2 | Kruppel-like factor 2 (lung) | 0.76 | 1.77 |
| 214702_at | Hs.203717 | FN1 | Fibronectin 1 | 1.74 | 1.64 |
| 242539_at | Hs.657550 | LOC730069 | Nuclear receptor binding factor 2 pseudogene | 1.06 | 2.26 |
| 226574_at | Hs.213198 | PSPC1 | Paraspeckle component 1 | 1.00 | 1.88 |
| 202434_s_at | Hs.154654 | CYP1B1 | Cytochrome P450 | 1.00 | 1.87 |
| 208711_s_at | Hs.523852 | CCND1 | Cyclin D1 | 1.00 | 2.07 |
| 229978_at | Hs.130661 | LOC440338 | Hypothetical gene supported by AJ002784 | 1.00 | 2.28 |
| 208153_s_at | Hs.591255 | FAT2 | FAT tumor suppressor homolog 2 (Drosophila) | 1.00 | 2.29 |
| 215462_at | Hs.632415 | PLK3 | Polo-like kinase 3 (Drosophila) | 1.00 | 2.08 |
| 1557049_at | Hs.700947 | LOC149478 | Hypothetical protein LOC149478 | 1.40 | 2.32 |
| 207332_s_at | Hs.529618 | TFRC | Transferrin receptor (p90) | 1.00 | 2.12 |
| 211984_at | Hs.282410 | CALM1 | Calmodulin 1 (phosphorylase kinase) | 1.00 | 2.33 |
| 200800_s_at | Hs.520028 | HSPA1 | Heat shock 70kDa protein 1A | 1.00 | 2.80 |
| 222853_at | Hs.41296 | FLRT3 | Fibronectin leucine rich transmembrane protein 3 | 1.00 | 3.14 |
| 205249_at | Hs.1395 | EGR2 | Early growth response 2 (Krox-20 homolog) | 1.64 | 2.78 |
| 222895_s_at | Hs.699440 | BCL11B | B-cell CLL/lymphoma 11B (zinc finger protein) | 1.00 | 3.69 |
| 1555847_a_at | Hs.436426 | LOC284454 | Hypothetical protein LOC284454 | 0.33 | 3.34 |
| 206393_at | Hs.523403 | TNNI2 | Troponin I type 2 (skeletal) | 1.00 | 3.64 |
| 206115_at | Hs.534313 | EGR3 | Early growth response 3 | 2.52 | 3.70 |
| 228523_at | Hs.591918 | NANOS1 | Nanos homolog 1 (Drosophila) | 1.00 | 5.08 |
a
Per Avadis software platform (Strand Life Sciences, San Francisco, CA).
b
Compared with control (0 µg/cm2 DEP).