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. Author manuscript; available in PMC: 2016 Dec 21.
Published in final edited form as: FEBS Lett. 2015 Nov 26;589(24 0 0):3959–3968. doi: 10.1016/j.febslet.2015.11.037

Fig. 3.

Fig. 3

Ranbp2−/−::Tg-Ranbp2CLDm-HA suppresses the development of apoptotic cell bodies by light-stress. The number of apoptotic cell bodies in 24-week-old Ranbp2−/−::Tg-Ranbp2CLDm-HA and wild type mice are scarce in the absence of light-stress and there is no difference between genotypes (A, B). In the presence of light stress (C, D), 24-week-old Ranbp2−/−::Tg-Ranbp2CLDm-HA show strong suppression of TUNEL+-apoptotic cell bodies (arrowheads) of photoreceptors in the central and peripheral regions of the retina compared to age-matched wild type mice. (B) and (D) are quantitative analyses of representative images in (A) and (C), respectively. Retinal sections were counterstained with DAPI. Data shown represent the mean ± S.D., n=5–6. Legend: NLT, non-light treatment; LT, light treatment (light stress); ONL, outer nuclear (cell bodies) layer of photoreceptors; +/+, wild type; −/-::Tg-Ranbp2CLDm-HA, Ranbp2−/−::Tg-Ranbp2CLDm-HA; n.s., non-significant; Scale bar: 20 μm.