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. 2016 Feb 5;11:607–624. doi: 10.2147/IJN.S98476

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© 2016 Hou et al. This work is published and licensed by Dove Medical Press Limited

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(A) The cellular uptake analyzed by fluorescence microscopy. a) FITC, b) FITC-labeled SWCNTs-HA, c) FITC-labeled SWCNTs-HA-ss-DOX, d) FITC-labeled Gd/SWCNTs-HA-ss-DOX, e) FITC-labeled Gd/SWCNTs-HA-DOX, f) SWCNTs-HA-ss-DOX, g) Gd/SWCNTs-HA-ss-DOX, h) Gd/SWCNTs-HA-DOX, and i) free DOX. (B) The intracellular distribution in MCF-7 cells analyzed by confocal microscopy. a) free DOX, b) free-HA pretreated Gd/SWCNTs-HA-ss-DOX, c) Gd/SWCNTs-HA-ss-DOX, and d) Gd/SWCNTs-HA-DOX.

Abbreviations: DOX, doxorubicin; FITC, fluorescein isothiocyanate; Gd, gadolinium; HA, hyaluronic acid; MCF-7, Michigan Cancer Foundation-7; SWCNTs, single-walled carbon nanotubes.