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Morphological studies of (A) AMCA-PLGA MP, (B) Chi-AMCA-PLGA MP, (C) AMCA-PLGA NP, and (D) Chi-AMCA-PLGA NP by SEM. Aqueous suspensions of representative particles were freeze-dried on specific grids and sputter coated with 8 nm platinum (holey carbon grids for MP, formvar-carbon grids for NP).
Abbreviations: AMCA-PLGA, 7-amino-4-methyl-3-coumarinylacetic acid-poly(d,l-lactide-co-glycolide); Chi, chitosan; MP, microparticles; NP, nanoparticles; SEM, scanning electron microscopy.
