Table 2. Extensive information of classification of genes in signaling pathways and cellular processes according to age groups.
| Gene | Gene Name | Early onset/Conventional | Classification | Corepathway | Cellular process |
|---|---|---|---|---|---|
| ABL1 | C-abl oncogene 1, non-receptor tyrosine kinase | Conventional | Oncogene | Cell Cycle/Apoptosis | Cell Survival |
| APC | Adenomatous polyposis coli | Early onset | Tumor suppressor gene | APC | Cell Fate |
| ATM | Ataxia telangiectasia mutated | Early onset/Conventional | Tumor suppressor gene | DNADamageControl | Genome Maintenance |
| CDH1 | Cadherin 1, type 1, E-cadherin (epithelial) | Early onset | Tumor suppressor gene | APC | Cell Fate |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | Early onset | Oncogene | APC | Cell Fate |
| FBXW7 | F-box and WD repeat domain containing7 | Conventional | Tumor suppressor gene | NOTCH | Cell Fate |
| FGFR2 | Fibroblast growth factor receptor 2 | Early onset | Oncogene | PI3K; RAS; STAT | Cell Survival |
| GNA11 | Guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | Conventional | Oncogene | PI3K; RAS; MAPK | Cell Survival |
| GNAS | GNAS complex locus | Conventional | Oncogene | APC; PI3K; TGF-β, RAS | Cell Survival/Cell Fate |
| JAK3 | Janus kinase 3 | Early onset/Conventional | Oncogene | STAT | Cell Survival |
| KRAS | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | Conventional | Oncogene | RAS | Cell Survival |
| MET | Met proto-oncogene (hepatocyte growth factor receptor) | Conventional | Oncogene | PI3K; RAS | Cell Survival |
| P16 | Cyclin-dependent kinase inhibitor 2A | Early onset/Conventional | Tumor suppressor gene | Cell Cycle/Apoptosis | Cell Survival |
| PIK3CA | Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, catalytic subunit alpha | Early onset/Conventional | Oncogene | PI3K | Cell Survival |
| RB1 | Retinoblastoma 1 | Early onset/Conventional | Tumor suppressor gene | Cell Cycle/Apoptosis | Cell Survival |
| SMAD4 | SMAD family member 4 | Conventional | Tumor suppressor gene | TGF-β | Cell Survival |
| STK11 | Serine/threonine kinase 11 | Early onset | Tumor suppressor gene | mTOR | Cell Survival |
| TP53 | Tumor protein p53 | Early onset/Conventional | Tumor suppressor gene | Cell Cycle/Apoptosis; DNADamageControl | Genome Maintenance |
| VHL | Von Hippel-Lindau tumor suppressor | Conventional | Tumor suppressor gene | PI3K; RAS; STAT | Cell Survival |
Adapted from Vogelstein et al. 2013 [9]