Fig. 4.

Effect of GLP-1 on control and βTpcn2 KO islets (A) Average Ca²⁺ responses showing mean ± SEM. (B, C) Quantification of the area under the curve (AUC) and peak of Ca²⁺ traces. (D) Insulin secretion from isolated islets from control (black) and βTpcn2 KO mice (blue). (E, F) Quantification of insulin secretion during the period from 2 to 32 min after the start of the experiment for the 17 mM glucose-stimulated islets, or from 10 to 32 min for the 11 mM glucose plus GLP-1-stimulated islets. The number of islets used for each set of experiments is shown on the bars in white. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)