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. Author manuscript; available in PMC: 2017 Feb 10.
Published in final edited form as: Annu Rev Physiol. 2015 Nov 2;78:481–504. doi: 10.1146/annurev-physiol-021115-105238

Figure 2.

Figure 2

Ecological modeling of the respiratory microbiome. (a) The constitution of the respiratory microbiome is determined by three factors: microbial immigration, microbial elimination, and the relative reproduction rates of its members. In health, community membership is determined primarily by immigration and elimination; in advanced lung disease, membership is determined primarily by regional growth conditions. Adapted with permission from Reference 28. (b) The adapted island model of lung biogeography. Community richness in health for a given site in the respiratory tract is a function of immigration and elimination factors. Adapted with permission from Reference 20.