Table 3.
Effect of pwSI on GABAergic neuron-related gene expression in distinct hippocampal regions of F344 rats
| CA1 |
CA3 |
DG |
||||
| Group | pwSI | Group | pwSI | Group | pwSI | |
| Gabra1 | 1.4E-02 ± 1.7E-03 | 1.4E-02 ± 2.2E-03 | 4.3E-03 ± 4.2E-04 | 3.9E-03 ± 3.2E-04 | 1.3E-02 ± 9.6E-04 | 9.0E-03± 3.2E-04c |
| Gabra2 | 4.4E-03 ± 8.0E-04 | 4.0E-03 ± 4.3E-04 | 3.8E-03 ± 2.2E-04 | 3.7E-03 ± 2.0E-04 | 9.6E-03 ± 9.2E-04 | 6.7E-03 ± 7.8E-04b |
| Gabra3 | nd | nd | 9.7E-05 ± 1.7E-05 | 1.6E-04 ± 8.9E-06 | 3.0E-04 ± 3.0E-05 | 2.6E-04 ± 3.6E-05 |
| Gabra4 | 1.1E-02 ± 2.5E-03 | 1.1E-02 ± 3.2E-03 | 3.1E-03 ± 3.3E-04 | 2.8E-03 ± 7.2E-05 | 2.6E-02 ± 1.4E-03 | 1.9E-02 ± 9.2E-04c |
| Gabra5 | 4.1E-02 ± 8.9E-03 | 3.9E-02 ± 1.3E-02 | 2.7E-02 ± 3.1E-03 | 3.4E-02 ± 3.9E-03 | 3.5E-02 ± 1.1E-03 | 2.7E-02 ± 2.4E-03a |
| Gabra6 | nd | nd | nd | nd | nd | nd |
| Gabrb1 | 1.1E-02 ± 2.4E-03 | 1.2E-02 ± 2.6E-03 | 6.5E-03 ± 6.3E-04 | 8.0E-03 ± 6.1E-04 | 1.8E-02 ± 1.9E-04 | 1.5E-02 ± 1.7E-03 |
| Gabrb2 | 1.2E-02 ± 3.0E-03 | 1.1E-02 ± 3.7E-03 | 3.0E-03 ± 1.1E-04 | 2.9E-03 ± 1.5E-04 | 1.2E-02 ± 1.4E-03 | 8.8E-03 ± 6.9E-04 |
| Gabrb3 | 4.7E-03 ± 8.8E-04 | 5.4E-03 ± 9.7E-04 | 2.7E-03 ± 7.6E-05 | 2.6E-03 ± 3.5E-04 | 1.1E-02 ± 1.6E-03 | 7.6E-03 ± 5.9E-04a |
| Gabrg1 | 3.1E-03 ± 8.5E-04 | 2.9E-03 ± 7.7E-04 | 1.4E-03 ± 1.5E-04 | 1.2E-03 ± 2.0E-04 | 4.4E-03 ± 6.2E-04 | 2.5E-03 ± 2.6E-04b |
| Gabrg2 | 2.9E-03 ± 9.0E-04 | 2.3E-03 ± 6.0E-04 | 1.1E-03 ± 2.0E-05 | 1.1E-03 ± 7.4E-05 | 4.8E-03 ± 1.2E-03 | 3.1E-03 ± 2.8E-05a |
| Gabrg3 | 2.0E-04 ± 5.1E-05 | 2.4E-04 ± 2.1E-05 | 1.2E-04 ± 3.3E-05 | 8.0E-05 ± 1.4E-05 | 5.9E-04 ± 1.7E-04 | 3.3E-04 ± 4.8E-05 |
| Gabrd | 2.6E-03 ± 5.1E-04 | 2.5E-03 ± 9.0E-04 | 4.0E-04 ± 8.7E-05 | 3.3E-04 ± 1.5E-05 | 1.9E-02 ± 2.4E-03 | 1.4E-02 ± 1.7E-03 |
| Gabbr1 | 2.1E-02 ± 2.3E-03 | 2.9E-02 ± 6.3E-03 | 7.9E-03 ± 8.6E-04 | 1.0E-02 ± 9.8E-04 | 2.1E-02 ± 1.9E-03 | 1.8E-02 ± 2.1E-04 |
| Gabbr2 | 2.5E-02 ± 3.9E-03 | 2.5E-02 ± 4.5E-03 | 2.2E-02 ± 2.6E-03 | 2.6E-02 ± 1.1E-03 | 4.9E-02 ± 2.6E-03 | 4.3E-02 ± 3.1E-03 |
| Slc32a1 | 4.5E-04 ± 1.0E-04 | 4.7E-04 ± 1.4E-04 | 2.8E-04 ± 4.9E-06 | 2.3E-04 ± 1.4E-05 | 4.1E-04 ± 4.2E-05 | 6.8E-04 ± 1.2E-04 |
| Slc6a1 | 4.1E-03 ± 1.3E-03 | 5.3E-03 ± 2.1E-03 | 2.3E-03 ± 2.9E-04 | 3.4E-03 ± 6.6E-04 | 7.5E-03 ± 1.1E-03 | 1.0E-02 ± 1.6E-03 |
| Gad1 | 3.1E-03 ± 5.6E-04 | 2.9E-03 ± 7.2E-04 | 1.1E-03 ± 4.6E-05 | 1.1E-03 ± 1.2E-04 | 5.6E-03 ± 3.7E-04 | 6.4E-03 ± 5.2E-04 |
| Gad2 | 2.8E-03 ± 6.5E-04 | 4.0E-03 ± 1.4E-03 | 1.2E-03 ± 9.9E-06 | 1.6E-03 ± 2.7E-04 | 5.2E-03 ± 9.4E-04 | 5.6E-03 ± 5.6E-04 |
nd, not detected
Data are shown as the mean ± SEM (n = 3) expression level relative to that of Gapdh.
Bold values indicate that the mean of pwSI/group >1.5
Italicized values indicate that the mean of pwSI/group < 0.7
Values differ significantly (aP < 0.05, bP < 0.01, and P < 0.001) between group-housed and pwSI rat.