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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Nat Neurosci. 2015 Aug 24;18(10):1464–1473. doi: 10.1038/nn.4095

Figure 7. Jq1 affects mouse behavior.

Figure 7

(a) Time spent in the inner or outer zone of an open field in mice treated with vehicle or with Jq1 for 1 or 3 weeks (for DMSO n = 10 mice, for 1 week Jq1 n = 9 mice, and for 3 weeks Jq1 n = 10 mice, two-way ANOVA (zone) P = 2E16, F = 598.57, two-way ANOVA (treatment) P = 0.986, F = 0.015, df = 54). (b) Novel object recognition paradigm. (c) Discrimination index of time spent with a novel vs familiar object one day after initial exposure to the objects (unpaired two-tailed t test, for DMSO n = 10 mice, for 1 week Jq1 n = 9 mice, and for 3 weeks Jq1 n = 10 mice, for DMSO vs 1 week Jq1 P = 0.0107, t = 2.88, for DMSO vs 3 weeks Jq1 P = 0.0094, t = 2.927, one sample t test for DMSO P = 0.00127, t = 4.85)..(d) Discrimination index of time spent with a novel vs familiar object one day after initial exposure after a single dose of Jq1 (unpaired two-tailed t test, n = 10 mice per group, for DMSO vs post-learning Jq1 P = 0.0376, t = 2.25, univariate analysis for DMSO P = 0.00262, t = 4.11). (e) Fear conditioning paradigm. (f) Percent of time spent freezing in a new context after fear conditioning (for DMSO n = 10 mice, for 1 week Jq1 n = 9 mice, and for 3 weeks Jq1 n = 10 mice, two-way ANOVA (treatment) P = 0.0135, F = 4.67 and unpaired two-tailed t test for DMSO vs 3 weeks Jq1 P = 0.0036, t = 3.34, df = 54). Discrimination index on a scale of −1 to 1: (% time with novel object − % time with familiar object)/(% time with novel object + % time with familiar object). ###, p<0.001 with univariate analysis. *, p<0.05. ***, p<0.001. n.s., nonsignificant. s, seconds. Error bars represent standard error.