Table 2. Mutations in HIV protease gene after previous virological failure (VF) on protease inhibitor-based regimen.
Protease mutations after previous VF on PI-based regimen (n = 158/205) | n (%) |
---|---|
Wild type | 59 (37.3) |
Only mm (M, 2; range, 1–7) | 48 (30.3) |
1 MM (L90M, 25; D30N, 11; V82A, 2; N88S, 2; I50L/V, 2) + mm (M, 3; range, 0–8) | 42 (26.6) |
2 MM (V82A + L90M, 5; I84V + L90M, 2; N88S + L90M, 2; V82A + I84V, 1; D30N | |
+ N88S, 1; I54L + L90M, 1;) + mm (M, 6; range, 4–10) | 12 (8.6) |
PI, protease inhibitor. mm, protease minor mutations. MM, HIV protease major mutations; M, median. Specific major protease mutations in brackets.