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. 2016 Feb 12;11(2):e0148955. doi: 10.1371/journal.pone.0148955

Fig 2. Differential gene expression analysis of HIV positive compared to HIV negative sepsis patient samples in the genomic response cohort reveal differential expression in several canonical pathways.

Fig 2

(A) Volcano plot representation (integrating log2 foldchange and multiple comparison adjusted p values) of differential gene expression comparing HIV positive and HIV negative sepsis patients. Horizontal line denotes the multiple comparison adjusted significance threshold (Benjamini-Hochberg (BH) p < 0.05). 149 unique genes were significantly differential (blue dots). (B) Over-expressed genes in HIV positive sepsis patients, as compared to HIV negative sepsis patients, associated to six canonical signaling pathways. Abbreviation:–log (BH) p: negative log10 transformed Benjamini-Hochberg adjusted Fisher’s exact p value. (C) Under-expressed genes in HIV positive sepsis patients, as compared to HIV negative sepsis patients, associated to four canonical signaling pathways. Abbreviation:–log (BH) p: negative log10 transformed Benjamini-Hochberg adjusted Fisher’s exact p value. (D) Expression of prominent genes in pathways differentially expressed between HIV positive and HIV negative sepsis patients. Data are depicted as box- and whisker plots depicting the smallest observation, lower quartile, median, upper quartile and largest observation. * = p<0.05, ** = p<0.01, *** = p<0.001.