Fig 4. Normalized expression of a validation set of seven genes in an independent cohort of ICU patients with sepsis recruited in a different time frame confirm over-expression in granzyme signaling, cytotoxic T-cell activation genes and T-cell inhibitory genes in HIV positive sepsis patients.

(A) Data are depicted as a supervised heatmap representation of significantly differential gene expression indices (BH-adjusted p-value < 0.05) between HIV- and HIV+ patients. Red, over-expressed; blue, under-expressed. (B) Data are also depicted as box- and whisker plots displaying the smallest observation, lower quartile, median, upper quartile and largest observation. * = p<0.05, ** = p<0.01, *** = p<0.001.