Table 1. Characteristics of Dutch ICU patients in the genomic response cohort and validation cohort.
| Genomic response cohort | Validaton cohort | |||||
|---|---|---|---|---|---|---|
| HIV+ n = 20 | HIV- n = 40 | P | HIV+ n = 12 | HIV- n = 24 | P | |
| Demographics | ||||||
| Male (%) | 17 (85.0) | 34 (85.0) | 1.0 | 8 (66.7) | 16 (66.7) | 1.0 |
| Age [IQR] | 48 [44–59] | 50 [43–61] | 0.86 | 48 [40–60] | 49 [40–60] | 0.76 |
| Race: white (%) | 12 (60.0) | 28 (70.0) | 0.56 | 9 (75.0) | 19 (79.2) | 0.79 |
| Race: black (%) | 7 (35.0) | 9 (22.5) | 0.36 | 2 (16.7) | 5 (20.8) | 1.0 |
| Race: asian (%) | 1 (5.0) | 2 (5.0) | 1.0 | 1 (8.3) | 0 (0.0) | 0.33 |
| Race: unknown (%) | 0 (1.7) | 1 (2.5) | 1.0 | — | — | — |
| Primary source of infection | ||||||
| Respiratory tract (%) | 11 (55.0) | 22 (55.0) | 1.0 | 11 (91.7) | 22 (91.7) | 1.0 |
| Central nervous system (%) | 4A (20.0) | 7 (17.5) | 1.0 | — | — | — |
| Skin or soft tissue (%) | 2 (10.0) | 5 (12.5) | 1.0 | — | — | — |
| Intra-abdominal (%) | 2 (10.0) | 5 (12.5) | 1.0 | — | — | — |
| Cardiovascular (%) | 0 (0.0) | 1 (2.5) | 1.0 | — | — | — |
| Urinary tract (%) | — | — | — | 1 (8.3) | 2 (8.3) | 1.0 |
| Primary bacteremia (%) | 1 (5.0)B | 0 (0.0) | 0.33 | — | — | — |
| Antiretroviral therapy (%) | 14 (70.0) | — | — | 5 (41.7) | — | — |
| CD4 count (cells/mm3) [IQR] | 290 [37–378] | 45 [13–124] | ||||
| Viral load (copies/ml) [IQR] | 100 [<50–20180] | 4.22x104 [<50–39.56x104] | ||||
| SOFA scoreC [IQR] | 9 [5–14] | 7 [4–9] | 0.14 | 6 [3–8] | 6 [4–8] | 0.83 |
| Organ failure (%) | 18 (90.0) | 29 (72.5) | 0.19 | 9 (75.0) | 19 (79.2) | 1.0 |
| Shock (%) | 5 (25.0) | 12 (30.0) | 0.78 | 2 (16.7) | 4 (16.7) | 1.0 |
| Outcome | ||||||
| ICU length of stay (days) [IQR] | 8 [1–11] | 5 [2–11] | 0.62 | 4 [3–14] | 7 [3–32] | 0.40 |
| Death in ICU (%) | 2 (10.0) | 6 (15.0) | 0.71 | 2 (16.7) | 5 (20.8) | 1.0 |
| 30-day mortality (%) | 7 (35.0) | 6 (15.0) | 0.10 | 2 (16.7) | 6 (25.0) | 0.69 |
| 90-day mortality (%) | 7 (35.0) | 12 (30.0) | 0.77 | 4 (33.3) | 11 (45.8) | 0.72 |
| 1-year mortality (%) | 8 (40.0) | 17 (42.5) | 1.0 | 5 (41.7) | 11 (45.8) | 1.0 |
P-values were calculated using fisher’s exact test for comparisons of categorical variables and Mann Whitney U tests or and unpaired t-tests for continuous variables.
Abbreviations: IQR: inter-quartile range, SOFA: sequential organ failure assessment, ICU: intensive care unit
A Including one patient with both central nervous system (CNS) and cardiovascular culture proven infection. This subject was matched to 1 control with CNS infection and 1 with cardiovascular infection.
B This patient was matched to two controls with either skin/soft tissue or abdominal sepsis since these two sites represented the possible sites of infection in the HIV positive patient.
C Without CNS score.