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. Author manuscript; available in PMC: 2017 Feb 15.
Published in final edited form as: Eur J Med Chem. 2015 Dec 23;109:216–237. doi: 10.1016/j.ejmech.2015.12.036

Table 6.

SAR exploration on the role of the X substituent on the B phenyl ring

graphic file with name nihms-751453-f0014.jpg
Compound X FAAHa IC50(μM)±SD COX-1a IC50 (μM)±SD COX-2a IC50 (μM)±SD
29a Cl 0.023±0.008 0.009±0.001 0.73±0.21
29b CH3 0.010±0.001 0.011±0.001 1.40±0.31
29c CF3 0.005± 0.001 0.01±0.003 0.2±0.08
29d OH 0.035±0.010 0.65±0.07 13.0 ±2.1
29e H 0.003±0.001 0.054±0.011 0.69±0.02
29f NO2 0.009±0.002 0.13±0.03 0.930±0.15
29g NH2 0.049±0.023 0.22±0.09 12.1±0.6
a

Values are reported as mean values of ≥3 experiments performed.