Table 6.
| ||||
---|---|---|---|---|
Compound | X | FAAHa IC50(μM)±SD | COX-1a IC50 (μM)±SD | COX-2a IC50 (μM)±SD |
29a | Cl | 0.023±0.008 | 0.009±0.001 | 0.73±0.21 |
29b | CH3 | 0.010±0.001 | 0.011±0.001 | 1.40±0.31 |
29c | CF3 | 0.005± 0.001 | 0.01±0.003 | 0.2±0.08 |
29d | OH | 0.035±0.010 | 0.65±0.07 | 13.0 ±2.1 |
29e | H | 0.003±0.001 | 0.054±0.011 | 0.69±0.02 |
29f | NO2 | 0.009±0.002 | 0.13±0.03 | 0.930±0.15 |
29g | NH2 | 0.049±0.023 | 0.22±0.09 | 12.1±0.6 |
Values are reported as mean values of ≥3 experiments performed.