Table 1. Selected analogues* of ethylbenzene.
Name | CAS No. | Correlation Coefficient | Rank* | PBPK ref. |
---|---|---|---|---|
Ethylbenzene | 100-41-4 | 1 | [58] | |
Xylene | 1330-20-7 | 0.999979 | 1 | [58] |
Toluene | 108-88-3 | 0.999957 | 3 | [58] |
Benzene | 71-43-2 | 0.999848 | 7 | [58] |
Dichloromethane | 75-09-2 | 0.988299 | 54 | [59] |
Methyl iodide | 21410-51-5 | 0.910114 | 283 | [60] |
*Chemical analogues were selected based on their similar published experimental designs (animal species = rats, route of administration = inhalation, time span = short term) relative to that of ethylbenzene-associated literature.
*The ranking of correlation coefficient among a total of 307 unique chemicals in the PBPK knowledgebase.