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. 2016 Feb 12;11(2):e0149000. doi: 10.1371/journal.pone.0149000

Fig 5. Cardiac function in hearts subjected to rhCCN2 postconditioning.

Fig 5

Cardiac function of hearts subjected to 25 min of ischemia and subsequently perfused in the absence or presence of rhCCN2 (250 nM) during the first 15 min of reperfusion. The figure demonstrates recording of heart rate (A), left ventricular end-systolic pressure, LVSP (B), left ventricular end-diastolic pressure (LVEDP) (C), and left ventricular developed pressure, LVDP (LVSP—LVEDP) (D) at baseline and during reperfusion after ischemia. LVEDP (C), illustrates the “ischemic contracture” of the Langendorff global ischemia system during ischemia. Recovery of LVDP is significantly increased in the group receiving recombinant human CCN2 during reperfusion (CCN2 25i). Data are mean, ± SEM for the first and last data point of N = 10 in each group. * P<0.05.