Table 1. Features of the lectin resistant HCV selections.
| Lectin | Dose (μg/mL) | Identified mutations (protein) | |
|---|---|---|---|
| Start | End | ||
| GNA | 1 | 30 | I30T¶ (Core) ; V284A (E1) ; V392D (E2) ; S449P* (E2) ; N2081H (NS5A) ; P2271S¶ (NS5A) ; I2340T (NS5A) ; C2441S¶ (NS5A) ; V2564A (NS5B) ; A2592V (NS5B) |
| CV-N | 0.1 | 2 | M338V (E1) ; L612M (E2) ; L755M (p7) ; F1926I (NS4B) ; I2270L¶ (NS5A) ; E2410G (NS5A) |
| ConA | 2 | 10 | T11A (Core) ; M338V (E1) ; N417S# (E2) ; L755M (p7) ; F1926I (NS4B) ; D2227V¶ (NS5A) ; K2542Q (NS5B) |
| GRFT | 1 | 1 | K12N (Core) ; M338V (E1) ; A400D (E2) ; L755M (p7) ; F1926I (NS4B) ; D2254G¶ (NS5A) ; M2275V (NS5A) ; Y2718H (NS5B) |
| Mock | - | - | I599V+ (E2) ; R1373Q+¶ (NS3) ; M1611T+¶ (NS3) ; S2364P+ (NS5A) ; C2441S+¶ (NS5A) ; R2523K+ (NS5B) |
*: This mutation prevents the modification of E2N4 N-glycosylation site on asparagine 448.
#: This mutation leads to a shift of the E2N1 N-glycosylation site and improves HCV entry.
+: These mutations have been characterized in a previous study [17].