Table 2. Conservation of the mutated amino acids.
| Mutation (protein) | % conservation (sequence number) | |
|---|---|---|
| all genotypes | genotype 2a | |
| V284 (E1) | 86.8% (2556/2945) | 95.2% (20/21) |
| M338 (E1) | 4.1% (122/2945) | 95.2% (20/21) |
| V392 (E2) | 11.2% (232/2073) | 22.2% (4/18) |
| A400 (E2) | 28.9% (599/2073) | 55.6% (10/18) |
| N417 (E2) | 97.6% (2024/2073) | 100% (18/18) |
| S449* (E2) | 84.0% (1741/2073) | 100% (18/18) |
| I599 (E2) | 1.7% (35/2073) | 72.2% (13/18) |
| L612 (E2) | 56.1% (1162/2073) | 88.9% (16/18) |
| L755 (p7) | 99.5% (1449/1456) | 100% (17/17) |
*: The mutation S449P prevents the modification of the E2N4 N-glycosylation site which is conserved in 97.6% of sequences of all genotypes and 100% of genotype 2a sequences.