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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Med Res Rev. 2015 Sep 23;36(2):313–341. doi: 10.1002/med.21379

Figure 7. BAM7 specifically binds Bax and induces Bax-dependent cell death.

Figure 7

a, The structure of BAM7 and its analog BTC-8. b, The specificity of BAM7 for the BH3 binding site on Bax was examined by competitive FPA employing FITC-BIM SAHB and Bcl-xLΔC (Only the result of BCL-xL is shown here). c, BAM7 selectively impairs the viability of Bak−/− MEFs but has no effect on MEFs lacking Bax (Bax−/−) or both Bax and Bak (Bax−/− Bak−/−). d. Bak−/− MEFs demonstrate the morphologic features of apoptosis in response to BAM7 treatment at the concentration of 15 μM. 1, 20 min; 2, 6 h; 3, 12 h; 4, 12.5 h. Scale bars, 15 μm. Reproduced, with permission, from REF. 164 © the Macmillan Publishers Limited (2012).