Table 2.
Top SNPs associated with diastolic blood pressure response to beta-blocker monotherapy in the meta-analysis with p < 5*10−7.
| SNP | CHR: Position | Nearest Gene | function | A1 | A2 | Freq_A1 | Beta | SE | P |
|---|---|---|---|---|---|---|---|---|---|
| rs1367094 | 8:40402374 | ZMAT4 | Intronic | T | C | 0.91 | −5.34 | 0.96 | 2.82E-08 |
| rs75165759 | 12:23922338 | SOX5 | intronic | T | C | 0.98 | −10.03 | 1.89 | 1.07E-07 |
| rs201279313 | 4:128657040:TTTA_ | SLC25A31 | intronic | D | R | 0.09 | −5.13 | 0.97 | 1.10E-07 |
| rs10456462 | 6:38166511 | BTBD9 | intronic | A | G | 0.18 | 3.32 | 0.64 | 2.33E-07 |
| rs7160625 | 14:35812484 | RP11- 561B11.3 |
intergenic | T | C | 0.16 | 3.36 | 0.65 | 2.60E-07 |
| rs143451596 | 3:175443589 | NAALADL2 | intronic | T | C | 0.97 | 7.88 | 1.55 | 3.98E-07 |
| rs3125734 | 10:63958112 | RTKN2 | missense | T | C | 0.64 | 2.58 | 0.51 | 4.38E-07 |
| rs7832003 | 8:10782004 | XKR6 | intronic | C | G | 0.13 | −3.51 | 0.70 | 4.81E-07 |
CHR: chromosome; Position: hg19 position. A1: allele 1; A2: allele 2. Freq: frequency; beta: regression coefficient for allele 1; SE: standard error of the beta coefficient. D: deletion; R: reference allele