Table 3.
Top SNPs associated with systolic blood pressure response to beta-blocker monotherapy in the meta-analysis with p < 5*10−7.
| SNP | CHR:position | Nearest Gene |
function | A1 | A2 | Freq_A1 | Beta | SE | P |
|---|---|---|---|---|---|---|---|---|---|
| rs76558488 | 5:10131285 | CTD- 2199O4.1 |
intergenic | A | G | 0.04 | 12.11 | 2.26 | 8.60E-08 |
| rs6663367 | 1:167147189 | RP11- 277B15.2 |
intergenic | A | C | 0.03 | 11.76 | 2.21 | 1.09E-07 |
| rs11313667 | 3:194082161:TC_T | LRRC15 | intronic | D | R | 0.74 | −4.90 | 0.93 | 1.49E-07 |
| rs1367094 | 8:40402374 | ZMAT4 | intronic | T | C | 0.91 | −7.92 | 1.51 | 1.55E-07 |
| rs142849141 | 11:87432794:TA_T | RP11- 720D4.3 |
intergenic | D | R | 0.07 | 7.58 | 1.48 | 2.99E-07 |
| rs114380097 | 3:30873418 | GADL1 | intronic | T | C | 0.95 | −10.76 | 2.10 | 3.04E-07 |
| rs35909283 | 8:70897741 | RN5S270 | intergenic | A | C | 0.04 | 11.67 | 2.31 | 4.19E-07 |
| rs7807739 | 7:50699557 | GRB10 | intronic | T | C | 0.05 | −9.08 | 1.80 | 4.61E-07 |
CHR: chromosome; Position: hg19 position. A1: allele 1; A2: allele 2. D: deletion; R: reference allele; Freq: frequency; Beta: regression coefficient for allele 1; SE: standard error of the beta coefficient