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. Author manuscript; available in PMC: 2016 Jul 27.
Published in final edited form as: Nature. 2016 Jan 27;530(7589):177–183. doi: 10.1038/nature16549

Figure 3. Brain RNA expression of C4A and C4B in relation to copy numbers of C4A, C4B, and the C4-HERV.

Figure 3

mRNA expression of C4A (a) and C4B (b) was measured (by ddPCR) in brain tissue from 244 individuals. Copy number of C4A, C4B, and the C4-HERV were measured (by ddPCR analysis of genomic DNA) in the brain donors. The results were consistent across 8 panels of brain tissue representing 5 brain regions and 3 distinct sets of donors (one set shown here, with data from 101 individuals; all panels in Extended Data Fig. 4; a few outlier points are beyond the range of these plots but are shown in Extended Data Fig. 4.) P-values were obtained by a Spearman rank correlation test. In panel c, expression of C4A (per genomic copy) is normalized to expression of C4B (per genomic copy) to control for trans-acting influences shared by C4A and C4B.