Table 3.
Factors associated with cardiac dysfunction among HIV infected children on combination antiretroviral therapy by univariate analysis
| Cardiac dysfunction
|
Total | Crude Odds Ratio (95% CI) | p-value | ||
|---|---|---|---|---|---|
| Present (39) | Absent (246) | ||||
| Age(yrs) | |||||
| < 5 | 3 | 41 | 44 | 1.00 | |
| ≥ 5 | 36 | 205 | 241 | 2.1 (0.635,7.40) | 0.22 |
| Gender | |||||
| Female | 22 | 132 | 154 | 1.00 | |
| Male | 17 | 114 | 131 | 0.71 (0.35,1.46) | 0.36 |
| Viral Load (copies/ml) | |||||
| <400 | 22 | 172 | 194 | 1.00 | |
| 400–5000 | 3 | 12 | 15 | 1.4(0.37,5.22) | 0.61 |
| >5000 | 11 | 8 | 19 | 0.96 (0.44,2.08) | 0.9 |
| CD4 Count (cells/mm3) | |||||
| <350 | 7 | 22 | 29 | 1.00 | |
| 350–750 | 9 | 62 | 71 | 0.5(0.32,1.00) | 0.16 |
| >750–1000 | 5 | 36 | 41 | 0.08 (0.137,1.141) | 0.19 |
| >1000 | 12 | 88 | 100 | 0.05 (0.171,1.013) | 0.11 |
| History of TB | |||||
| Yes | 10 | 73 | 83 | 1.00 | |
| No | 29 | 173 | 202 | 1.26(0.56,2.82) | 0.56 |
| ART | |||||
| First line | 28 | 177 | 205 | ||
| second line | 11 | 69 | 80 | 0.8(0.37,1.86) | 0.66 |
| Duration from HIV diagnosis | |||||
| <5yrs | 19 | 109 | 128 | ||
| ≥5yrs | 20 | 137 | 157 | 0.89 (0.44,1.81) | 0.77 |
| Duration of ART | |||||
| <5yrs | 22 | 144 | 166 | 1.00 | |
| ≥5yrs | 17 | 102 | 119 | 0.99 (0.49,2.02) | 0.99 |
CI – confidence interval; TB – Tuberculosis; ART – antiretroviral therapy