Table 4.

Joint associations of CRAE and PDSA with incident CVD

Group	Person year	Number of CVD cases	Incident rate	IRR (95 % CI)	p value
1	20,681	149	7.2 (6.1, 8.5)	1
2/3	10,758	133	12.4 (10.4, 14.6)	1.53 (1.17, 2.00)	0.002
4	392	11	2.8 (1.6, 50.7)	3.41 (1.79, 6.50)	<0.001

Group 1: No PDSA and two higher tertiles of CRAE (n=3,682); Group 2: No PDSA and lowest tertile of CRAE (n=1,817); Group 3: PDSA and two higher tertiles of CRAE (n=121); Group 4: PDSA and lowest tertile of CRAE (n=76). Model: Adjusted for age, gender, race/ethnicity, BMI, cigarette smoking, diabetes mellitus, total cholesterol, HDL, triglycerides, diastolic blood pressure, antihypertensive medication use, statin use, benzodiazepine use, current alcohol use, and CRVE

IRR incidence rate ratios, 95 % CI 95 % confidence interval, CRAE central retinal artery equivalent, PDSA physician-diagnosed sleep apnea, CVD cardiovascular disease

Numbers set in bold indicate p<0.05