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Deficiency of Cav-1 prevents Ang II-mediated hypertrophy and inward remodeling in pial arterioles. Cross-sectional area of pial arteriolar wall in WT and Cav-1−/− mice treated with saline or Ang II (A); Cross-sectional area of pial arteriolar wall in WT and MMP9−/− mice treated with saline or Ang II. (B): Pressure–diameter relationship of maximally dilated pial arterioles in wild-type (WT) and MMP9−/− mice treated with saline or Ang II.
