Table 2.
Physiological data for wild-type (WT) and MMP9-deficient mice treated with angiotensin II (Ang II) (1000ng/kg/min) or saline for 4 weeks. Systolic arterial pressure was measured by tail cuff method in conscious mice at week 4 of Ang II treatment. Pial arteriolar pressure was measured under anesthetized condition.
| Parameters | WT Saline |
WT Ang II |
MMP9−/− Saline |
MMP9−/− Ang II |
|---|---|---|---|---|
| Systolic Arterial Pressure (mmHg) | ||||
| Week 4 | 114 ± 5 | 154 ± 6* | 117 ± 4 | 157 ± 4* |
| Pial arteriolar pressure (mmHg) | ||||
| Systolic | 48 ± 4 | 41 ± 5 | 51 ± 4 | 46 ± 2 |
| Diastolic | 34 ± 4 | 30 ± 4 | 38 ± 2 | 32 ± 2 |
| Mean | 38 ± 4 | 34 ± 4 | 42 ± 3 | 37 ± 2 |
| Pulse | 14 ± 1 | 11 ± 2 | 13 ± 2 | 13 ± 1 |
| Arterial blood gases | ||||
| pH | 7.49 ± 0.02 | 7.30 ± 0.03 | 7.30 ± 0.04 | 7.47 ± 0.02 |
| PCO2 | 22 ± 2 | 44 ± 4 | 35 ± 2 | 28 ± 5 |
| PO2 | 168 ± 4 | 97 ± 5 | 122 ± 2 | 136 ± 6 |
| Age (week) | 13 ± 0.3 | 17 0.8 | 12 ± 0.4 | 18 ± 0.5 |
| Weight (g) | 25.0 ± 0.9 | 24.5 ± 1.4 | 26.6 ± 1.2 | 23.9 ± 1.1 |
| N | 6 | 6 | 6 | 6 |
Values are mean±SEM.
*
P<0.05 versus corresponding saline controls.