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. Author manuscript; available in PMC: 2017 May 1.
Published in final edited form as: Pediatr Nephrol. 2015 Aug 12;31(5):715–723. doi: 10.1007/s00467-015-3181-8

Figure 1.

Figure 1

Olfactory receptor (OR) signaling pathways. A) The canonical OR signaling pathway in the olfactory epithelium. OR-ligand binding activates Golfactory (Golf) leading to increased cAMP via Adenylate Cyclase 3 (AC3) and the subsequent depolarization of olfactory sensory neurons. B) The potential OR signaling pathways in the kidney. As Golf and AC3 are not ubiquitous in the nephron, it is likely that an activated renal OR binds a stimulatory G protein (Gs) leading to cAMP production by different adenylate cyclases and changes in renal function.