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Short chain fatty acids (SCFAs) produced by the gut microbiota activate Olfr78 in the both the renal juxtaglomerular apparatus (JGA) and peripheral vasculature. Activation of Olfr78 in the JGA leads to increased renin release. In the peripheral vasculature, activation of Olfr78 modulates a hypotensive response mediated by other SCFA receptors. In both cases, activation of Olfr78 leads to an increased blood pressure response.
