Table I.
Identified Renal Olfactory Receptors (ORs)
| OR | Species | Method of Detection |
Localization | Ligands | References |
|---|---|---|---|---|---|
| Olfr78 | Mouse | RT-PCR Microarray |
Afferent arteriole Isolated JG Cells |
Short chain fatty acids | [59; 64] [61] |
| (Ortholog of Olr59 and OR51E2) | |||||
| Olr59 | Rat | RNA-seq | Glomeruli | - | [63] |
| (Ortholog of Olfr78 and OR51E2) | |||||
| OR51E2 | Human | RNA-seq | - | Propionate | [62; 86] |
| (Ortholog of Olfr78 and Olr59) | Acetate β-ionone Steroid hormones |
||||
| Olfr90 | Mouse | RT-PCR | Macula Densa | - | [59] |
| Olfr1392 | Mouse | RT-PCR | - | - | [59] |
| Olfr1393 | Mouse | RT-PCR | - | - | [59] |
| Olfr99 | Mouse | RT-PCR | - | - | [59] |
| Olfr545 | Mouse | RT-PCR | - | Sebacic acid* | [60; 87] |
| Olfr691 | Mouse | RT-PCR | - | Short and medium chain fatty acids |
[60; 68] |
| Olfr693 | Mouse | RT-PCR | - | - | [60] |
| Olfr31 | Mouse | RT-PCR | - | - | [60] |
| Olfr1426 | Mouse | RT-PCR | - | - | [60] |
| Olfr95 | Mouse | Microarray | Isolated JG Cells | - | [61] |
| Olfr796 | Mouse | Microarray | Isolated JG Cells | - | [61] |
| Olfr1303 | Mouse | Microarray | Isolated JG Cells | - | [61] |
| Olfr239 | Mouse | Microarray | Isolated JG Cells | - | [61] |
| Olfr1200 | Mouse | Microarray | Isolated JG Cells | - | [61] |
| Olfr373 | Mouse | Microarray | Isolated JG Cells | - | [61] |
| Olfr558 | Mouse | Microarray | Isolated JG Cells | - | [61] |
| Olr1104 | Rat | RNA-seq | DCT | - | [63] |
| Olr1694 | Rat | RNA-seq | S3, LDLIM, tAL, IMCD, Glomeruli |
- | [63] |
| Olr560 | Rat | RNA-seq | Entire nephron, Glomeruli |
- | [63] |
| Olr63 | Rat | RNA-seq | Glomeruli | - | [63] |
| OR10A2 | Human | RNA-seq | - | - | [62] |
| OR1L8 | Human | RNA-seq | - | - | [62] |
| OR2A1 | Human | RNA-seq | - | - | [62] |
| OR2A42 | Human | RNA-seq | - | - | [62] |
| OR2A7 | Human | RNA-seq | - | - | [62] |
| OR2AG1 | Human | RNA-seq | - | Amylbutyrate | [62; 88] |
| OR2T10 | Human | RNA-seq | - | Maltyl isobutyrate, cinnamaldehyde, vanillin, terpinyl acetate and α- damascone |
[62; 89] |
| OR51E1 | Human | RNA-seq | - | Methyl valeric acid, valeric acid and isovaleric acid |
[62; 90] |
| OR51I1 | Human | RNA-seq | - | - | [62] |
| OR51I2 | Human | RNA-seq | - | - | [62] |
| OR56B1 | Human | RNA-seq | - | - | [62] |
| OR9A4 | Human | RNA-seq | - | - | [62] |
JG Cells, Juxtaglomerular cells; DCT, distal convoluted tubule; S3, third segment of proximal tubule; LDLIM, long descending limb of the loop of Henle in the inner medulla; tAL, thin ascending limb of the loop of Henle; IMCD, inner medullary collecting duct