Table 1. Sex differences in BACHD activity rhythm parameters.
Effects of sex and age on BACHD mouse locomotor activity rhythm parameters (DF = 63).
| WT | BACHD | ||||
| 3 months | Male (n = 8) | Female (n = 8) | Male (n = 8) | Female (n = 8) | |
| LD | % V | 57.0 ± 6.6 | 68.1 ± 7.5 | 41.7 ± 6.8^ | 47.1 ± 10.3^^^ |
| Activity (rev/hr) | 984 ± 162 | 1240 ± 213 | 627 ± 200^^ | 1093 ± 138*** | |
| % Activity in Light | 8.8 ± 4.5 | 19.8 ± 11.3* | 14.8 ± 8.2 | 23.3 ± 7.4 | |
| Alpha (min) | 663 ± 118 | 690 ± 48.2 | 727 ± 41.8 | 712 ± 56.8 | |
| Imprecision (min) | 18.6 ± 10.4 | 11.8 ± 4.7 | 32.7 ± 11.0 | 21.0 ± 7.7 | |
| Fragmentation (bouts/day) | 5.5 ± 1.2 | 4.8 ± 0.5 | 5.5 ± 1.1 | 4.6 ± 0.7 | |
| LD-DD Phase angle (min) | 53.3 ± 48.5 | -7.6 ± 19.1* | 22.0 ± 23.8 | 10.5 ± 34.3 | |
| DD | Period (hr) | 23.8 ± 0.2 | 23.7 ± 0.1 | 23.9 ± 0.1 | 23.9 ± .1 |
| % V | 55.5 ± 9.6 | 63.2 ± 12.4 | 44.1 ± 7.5 | 46.5 ± 7.4 | |
| Activity (rev/hr) | 1080 ± 75 | 1250 ± 257 | 681 ± 187^^^ | 1190 ± 99*** | |
| Alpha (min) | 570 ± 42 | 639 ± 78* | 643 ± 102^ | 651 ± 64^* | |
| Imprecision (min) | 25.2 ± 14.2 | 11.7 ± 5.5*** | 12.6 ± 4.6^ | 11.8 ± 4.7 | |
| Fragmentation (bouts/day) | 4.7 ± 0.8 | 4.8 ± 0.8 | 5.7 ± 1.6 | 5.7 ± 1.1 | |
| CT16 LP (min) | 112 ± 32 | 125 ± 23 | 82.6 ± 19.4 | 120 ± 15** | |
| WT | BACHD | ||||
| 6 months | Male (n = 8) | Female (n = 8) | Male (n = 8) | Female (n = 8) | |
| LD | % V | 65.0 ± 8.0 | 66.4 ± 7.9 | 25.9 ± 6.1^^^## | 33.7 ± 9.2^^^## |
| Activity (rev/hr) | 948 ± 177 | 1070 ± 169 | 474 ± 201^^^ | 621 ± 178^^^### | |
| % Activity in Light | 2.5 ± 1.5 | 4.3 ± 2.8## | 26.0 ± 12.5^^^# | 13.6 ± 3.6*# | |
| Alpha (min) | 524 ± 57.9### | 692 ± 38.6*** | 731 ± 92.6^^^ | 736 ± 40.8 | |
| Imprecision (min) | 6.9 ± 1.9 | 13.9 ± 4.9** | 55.5 ± 27.3^^^## | 27.5 ± 12.5*** | |
| Fragmentation (bouts/day) | 4.0 ± 1.0# | 3.6 ± 0.6 | 9.2 ± 1.5^^^### | 6.9 ± 1.3^^*## | |
| LD-DD Phase angle (min) | -3.5 ± 32.4 | -27.9 ± 15.4 | 32.3 ± 24.4 | 15.5 ± 24.9 | |
| DD | Period (hr) | 23.8 ± 0.2 | 23.8 ± 0.1 | 23.8 ± 0.2 | 23.7 ± 0.1*## |
| % V | 53.0 ± 12.9 | 59.4 ± 6.7 | 27.8 ± 8.1^^^ | 29.9 ± 5.2^^^ | |
| Activity (rev/hr) | 872 ± 177 | 1040 ± 126# | 474 ± 192^^ | 590 ± 205^^^### | |
| Alpha (min) | 557 ± 23 | 619 ± 69* | 612 ± 134^ | 690 ± 52^* | |
| Imprecision (min) | 25.1 ± 6.1 | 13.5 ± 5.8*** | 23.1 ± 6.5## | 23.2 ± 13.2## | |
| Fragmentation (bouts/day) | 5.4 ± 1.1 | 4.0 ± 0.7 | 9.1 ± 0.8^^^### | 7.5 ± 1.4^^^*# | |
| CT16 LP (min) | 60.3 ± 35.9### | 103 ± 19* | 69.1 ± 10.2 | 90.4 ± 20.7# | |
When main or interaction effects were identified, significant genotypic differences within sex and age, sex differences within age and genotype, and age differences within sex and genotype were identified post-hoc using the Holm-Sidak method for multiple pairwise comparisons
^Genotype, P < 0.05;
^^Genotype, P < 0.01;
^^^Genotype, P < 0.001;
*Sex, P < 0.05;
**Sex, P < 0.01;
***Sex, P < 0.001;
#Age, P < 0.05;
##Age, P < 0.01;
###Age, P < 0.001
Reported values are means ± 95% CI.