Table 3. Impact of baseline treatment with inhibitors of gastric acid secretion on study outcomes.
Multivariate
| HR | 95% CI | p | Control variables | |
|---|---|---|---|---|
| Enteric peritonitis | Age, Immunosuppression, GFR, C reactive protein | |||
| IGAS overall | 1.65 | 1.08, 2.55 | 0.018 | |
| PPI | 1.61 | 0.98, 2.51 | 0.059 | |
| H2A | 1.67 | 1.02, 2.80 | 0.042 | |
| Infectious mortality | Age, diabetes, Charlson, albumin, Immunossuppresion, GFR | |||
| IGAS overall | 1.09 | 0.65, 1.82 | 0.75 | |
| PPI | 0.68 | 0.35, 1.32 | 0.26 | |
| H2A | 1.78 | 1.01, 3.21 | 0.049 | |
| Overall peritonitis | Age, albumin, immunosuppression, GFR, modality of PD | |||
| IGAS overall | 1.18 | 0.95, 1.47 | 0.11 | |
| PPI | 1.23 | 0.96, 1.59 | 0.10 | |
| H2A | 1.08 | 0.80, 1.47 | 0.61 | |
| Overall mortality | Age, diabetes, Charlson, albumin, immunossuppresion, GFR | |||
| IGAS overall | 0.96 | 0.76, 1.23 | 0.76 | |
| PPI | 0.85 | 0.64, 1.13 | 0.26 | |
| H2A | 1.15 | 0.85, 1.55 | 0.37 |
IGAS: Inhibitors of gastric acid secretion; PPI: Proton pump inhibitors; H2A: H2 receptor antagonists.
* Independent predictors of outcome in best model. PD vintage NS
Stepwise Cox models. Figures denote adjusted hazard ratios (HR) with 95% confidence intervals and p values for the main outcome variables.