Table 4. Impact of treatment with inhibitors of gastric acid secretion on study outcomes.
Time dependent, multivariate analysis.
| HR | 95% CI | p | Control variables | |
|---|---|---|---|---|
| Enteric peritonitis | Diabetes, Charlson, albumin, immunosuppression, hemoglobin, GFR | |||
| IGAS overall | 1.33 | 1.02, 1.75 | 0.040 | |
| PPI | 1.08 | 0.70, 1.66 | 0.74 | |
| H2A | 1.45 | 0.92, 2.29 | 0.11 | |
| Infectious mortality | Age, diabetes, Charlson, albumin, immunosuppression, hemoglobin, GFR | |||
| IGAS overall | 1.61 | 1.14, 2.27 | 0.007 | |
| PPI | 0.90 | 0.52, 1.49 | 0.62 | |
| H2A | 2.03 | 1.19, 3.47 | 0.01 | |
| Overall peritonitis | Age, albumin, immunosuppression, GFR, hemoglobin, modality of PD | |||
| IGAS overall | 1.09 | 0.95, 1.60 | 0.24 | |
| PPI | 1.32 | 0.95, 1.66 | 0.17 | |
| H2A | 0.97 | 0.74, 1.26 | 0.80 | |
| Overall mortality | Age, diabetes, Charlson, albumin, immunosuppression, hemoglobin, GFR | |||
| IGAS overall | 1.11 | 0.93, 1.31 | 0.24 | |
| PPI | 0.94 | 0.76, 1.29 | 0.94 | |
| H2A | 1.16 | 0.88, 1.53 | 0.31 |
IGAS: Inhibitors of gastric acid secretion; PPI: Proton pump inhibitors; H2A: H2 receptor antagonists.
* Independent predictors of outcome in best model. PD vintage NS
Time dependent Cox’s models. Figures denote adjusted hazard ratios (HR) with 95% confidence intervals and p values for the main outcome variables.