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. 2016 Feb 12;11(2):e0148313. doi: 10.1371/journal.pone.0148313

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© 2016 Oudejans et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — By targeted methyl-C DNA sequencing (principle explained in A), DMR1 (see Table 3) was analyzed. Within the 80 bp region analyzed (B), 2 patterns were found after bisulfite sequencing. Strands were either completely unmethylated (B1) or hemimethylated at 4 sites presenting as heterozygous calls (B1+B2). For comparison, the converted upper strand is shown (B3). The unaffected twins showed hemimethylation of 4 (boxes) out of 16 methylation sensitive C nucleotides (C1+C2) and hypomethylation (loss of methylation) in affected twins (C3+C4). Open circle: unmethylated, closed circle: methylated.