Table 1. Concentration-dependence of incidence of spontaneous and provoked atrial arrhythmia, APDx values, activation latency, AERP, AERP/latency and AERP/APD90 ratios.
| Parameter | heptanol concentration (mM) | n (all concentrations) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| control | 0.1 | P | 0.5 | P | 1 | P | 2 | P | ||
| spontaneous arrhythmia | 0 out of 11 | 0 out of 11 | N.S. | 0 out of 11 | N.S. | 0 out of 11 | N.S. | 0 out of 11 | N.S. | 11 |
| inducible arrhythmia | 5 out of 10 | 2 out of 10 | N.S. | 4 out of 10 | N.S. | 4 out of 10 | N.S. | 0 out of 10 | < 0.05 | 10 |
| APD90 | 25.2 ± 1.0 | 24.3 ± 1.6 | N.S. | 24.6 ± 1.3 | N.S. | 25.6 ± 1.1 | N.S. | 25.8 ± 1.8 | N.S. | 7 |
| APD70 | 13.9 ± 0.5 | 12.6 ± 1.8 | N.S. | 13.8 ± 1.3 | N.S. | 15.7 ± 1.2 | N.S. | 14.0 ± 1.3 | N.S. | 7 |
| APD50 | 8.2 ± 0.9 | 8.3 ± 1.8 | N.S. | 9.2 ± 1.3 | N.S. | 9.9 ± 1.3 | N.S. | 8.6 ± 1.2 | N.S. | 7 |
| APD30 | 4.3 ± 0.5 | 5.2 ± 1.0 | N.S. | 5.8 ± 1.0 | N.S. | 6.6 ± 1.1 | N.S. | 5.6 ± 1.0 | N.S. | 7 |
| activation latency | 21.9 ± 1.3 | 23.0 ± 3.1 | N.S. | 21.9 ± 2.8 | N.S. | 23.9 ± 3.1 | N.S. | 29.5 ± 1.8 | < 0.01 | 10 |
| AERP | 34.4 ± 2.8 | 32.9 ± 4.7 | N.S. | 39.6 ± 5.8 | N.S. | 41.1 ± 6.1 | N.S. | 60.0 ± 1.9 | < 0.001 | 10 |
| AERP/latency ratio | 1.6 ± 0.1 | 1.5 ± 0.1 | N.S. | 1.8 ± 0.2 | N.S. | 1.8 ± 0.2 | N.S. | 2.1 ± 0.2 | < 0.05 | 10 |
| AERP/APD ratio | 1.3 ± 0.1 | 1.4 ± 0.2 | N.S. | 1.6 ± 0.2 | N.S. | 1.6 ± 0.2 | N.S. | 2.3 ± 0.1 | < 0.001 | 7 |