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. 2016 Feb 8;28(2):021304. doi: 10.1063/1.4941315

FIG. 9.

FIG. 9.

In vivo two-photon excited fluorescence imaging of vascular topology and cerebral blood flow during the cardiac cycle: (a) and (c) Low-magnification image of the fluorescently labeled brain vasculature in an anesthetized mouse. (b) Three-dimensional rendering of the vasculature with the brain surface at the top of the image. (d) Pulsatile red blood cell flow speed across the spatial profile of an arteriole over the cardiac cycle. Reprinted with permission from Santisakultarm et al., “In vivo two-photon excited fluorescence microscopy reveals cardiac-and respiration-dependent pulsatile blood flow in cortical blood vessels in mice,” Am. J. Physiol.: Heart Circ. Physiol. 302, H1367–H1377 (2012). Copyright 2012 American Journal of Physiology — Heart and Circulatory Physiology.