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. 2015 Oct 3;43:233–248. doi: 10.1007/s10295-015-1686-6

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — a The chemical structure of daunorubicin and doxorubicin (Prod. S. peucetius). b Crystal structure of DNA-doxorubicin associated complexes. The tetracyclic rings intercalate between base pairs while the aminosugar rests in the minor groove of DNA (PDB:1D12)