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. 2015 Mar 3;87(2):130–137. doi: 10.1136/jnnp-2014-309932

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Effects of long-term treatment with interferon β (IFNβ) on Tumour necrosis factor-Related Apoptosis Inducing Ligand TRAILR-2 isoform 2 and TRAIL-α expression. Expression levels are represented as relative expression compared with the reference gene GAPDH, using the ΔΔCt method. Expression before and after 1 year of IFNβ therapy in the same individual patients is plotted. (A) Long-term therapy with IFNβ significantly decreased mRNA expression of TRAILR-2 isoform 2 in monocytes from patients who will become responders (R) as well as those who will become non-responders (NR) to treatment. (B) TRAIL-α mRNA expression in CD4+ and CD8+ T cells significantly increased along with IFNβ therapy, but only in responders.