Table 2.

Pregnancy course and outcomes

	Characteristics at start pregnancy			Obstetrics						Treatment in pregnancy		Events during pregnancy
Case	Maternal age	Clinically recognised ARVD/C	High-risk pregnancy	GP*	Result	Duration	Delivery	Obstetric complications	Child's age at last follow-up	Medication	ICD	Increase symptoms	VA	HF onset
1	27	Yes	VA+RV structure	G1P0	Live birth	35 weeks	Vaginal	No	2 years	B, dose *2	Yes	Palpitations/PVCs	No	No
	30	Yes		G2P1	Miscarriage	<13 weeks
	30	Yes	VA+RV structure	G3P1	Live birth	Full term	Vaginal	No	2 months	B, add flecainide in second trimester	Yes	Palpitations/PVCs	No	No
2	30	Yes	No	G2P1	Live birth	Full term	Vaginal	No	10 years	None	Yes	Fatigue, palpitations	No	No
	40	Yes	No	G3P2	Live birth	Full term	Vaginal	No	12 months	Start B in 23rd week	Yes	PVCs/NSVTs	No	No
3	37	Yes	VA+RV structure	G1P0	Live birth	Full term	Vaginal	Dysmaturity	2 years	B+ diuretics when needed	Yes	Dyspnoea, palpitations	No	Yes
4	32	Yes	VA	G1P0	Live birth	Full term	C-section	No	4 years	Sotalol	No	No	No	No
	33	Yes	VA	G2P1	Live birth	Full term	C-section	No	2 years	Sotalol	Yes	No	No	No
	36	Yes		G3P2	Miscarriage	<13 weeks
5	29	Yes	No	G1P0	Live birth	34 weeks	C-section	Preterm contractions	1 month	Sotalol+diuretics≤7 days	Yes	Mild dyspnoea	No	No
6	28	Yes	RV structure	G1P0	Live birth	Full term	Vaginal	Child: scalp laceration infection due to use of vacuum	5 years	B; change atenolol to metoprolol	Yes	Palpitations	Third week: ICD discharge	No
7	33	Yes	VA+RV structure	G1P0	Live birth	Full term	C-section	No	9 months	B	Yes	No	No	No
8	28	Yes	VA	G1P0	Live birth	Full term	Vaginal	No	9 months	B	Yes	No	No	No
9	29	Yes		G1P0	Miscarriage	<13 weeks
	30	Yes	No	G2P0	Live birth	Full term	Vaginal	No	4 years	B	Yes	No	No	No
	31	Yes	No	G3P1	Live birth	Full term	Vaginal	Temporary intrauterine growth restriction	3 years	Stop B→VA→restart B	Yes	No	18th week: antitachycardia pacing	No
	33	Yes	VA	G4P2	Live birth	Full term	Vaginal		23 months	B	Yes	No	No	No
	34	Yes	VA	G5P3	Live birth	Full term	Vaginal	Meconium-stained amniotic fluid	3 months	B	Yes	No	No	No
10	24	Yes	No	G1P0	Live birth	Full term	Vaginal	No	6 years	None (stop B in 4th–8th week)	Yes	No	No	No
	26	Yes	No	G2P1	Live birth	Full term	Vaginal	Preterm contractions	5 years	None (stop B in 4th–8th week)	Yes	No	No	No
	28	Yes	No	G3P2	Live birth	Full term	Vaginal	No	3 years	None (stop B in 4th–8th week)	Yes	No	No	No
11	31	Yes	RV structure	G1P0	Live birth	Full term	C-section	No	5 years	B; stop valsartan; 22nd week: + diuretics; 32nd week: + digoxin, increase diuretics	Yes	Dyspnoea, oedema, fatigue	No	Yes
12	33	Yes	No	G3P1	Live birth	Full term	Vaginal	No	2 years	None	Yes	No	No	No
13	30	Yes	RV structure	G1P0	Live birth	Full term	C-section	Child: hypoglycaemia in macrosomia	16 years	None	Yes	No	No	No
	34	Yes		G2P1	Miscarriage	<13 weeks						No		No
	35	Yes	RV structure	G3P1	Live birth	Full term	C-section	No	11 years	None	Yes	No	No	No
14	25	Yes	RV structure	G1P0	Live birth	Full term	Vaginal	No	3 years	None	Yes	No	No	No
	27	Yes		G2P1	Miscarriage	<13 weeks						No		No
	28	Yes	RV structure	G3P1	Live birth	Full term	Vaginal	No	Newborn	None	Yes	No	No	No
15	32	Yes	No	G5P2	Live birth	Full term	Vaginal	No	3 years	None	No	No	No	No
16	34	Yes	No	G2P1	Live birth	Full term	Vaginal	No	18 months	None	No	No	No	No
17	32	Yes	No	G3P2	Live birth	Full term	Vaginal	No	2 years	B	Yes	Palpitations/PVCs	No	No
18	32	Yes	No	G2P1	Live birth	Full term	Vaginal	No	4 months	None	No	No	No	No
19	31	No	No	G1P0	Live birth	Full term	C-section	No	9 years	None	No	No	No	No
	33	No	No	G2P1	Live birth	Full term	C-section	No	7 years	Start B since VA	Yes	Palpitations	12 weeks: VT	No
20	23	No	No	G2P1	Live birth	Full term	Vaginal	No	9 years	None	No	No	No	No
21	32	No	No	G2P1	Live birth	Full term	C-section	No	18 months	Stop B in 4th week →VA→start sotalol	Yes	PVCs	6th week: VT+short VF	No
22	34	No	No	G3P2	Live birth	Full term	Vaginal	No	6 years	None	No	No	No	No
23	34	No	No	G3P2	Live birth	Full term	C-section	No	6 years	None	No	No	No	No
24	29	No	No	G2P1	Live birth	Full term	Vaginal	No	22 years	None	No	Palpitations/PVCs	No	No
	31	No		G3P2	Miscarriage	<13 weeks
	31	No	RV structure	G4P2	Live birth	Full term	Vaginal	No	19 years	None	No	Fatigue	No	No
25	31	No	No	G1P0	Live birth	Full term	Vaginal	No	3 years	Start B since VA	Yes	No	6 weeks: VT	No
	32	Yes	No	G2P1	Live birth	Full term	Vaginal	No	2 years	B, dose *2 when needed	Yes	Palpitations	No	No
26	25	No	No	G1P0	Live birth	Full term	Vaginal	Meconium stained amniotic fluid	5 years	None	No	No	No	No

*Gravidity–parity: gravidity refers to the number of times a subject has been pregnant including the current pregnancy, parity to the number of times a subject has given birth to a fetus with a gestational age of 24 weeks or more.

ARVD/C, arrhythmogenic right ventricular dysplasia/cardiomyopathy; B, β blocker; C-section, caesarean section; GP, gravidity–parity; HF, heart failure ≥ Class C¹⁹; ICD, implantable cardioverter defibrillator; NSVT, non-sustained ventricular tachycardia; PVC, premature ventricular complex; RV structure, structural abnormalities of the right ventricle that met major structural 2010 Task Force Criteria¹⁶; VA, sustained ventricular arrhythmia or appropriate ICD therapy for a ventricular arrhythmia; VF, ventricular fibrillation; VT, sustained ventricular tachycardia.