Figure 3.

IFN-I Promotes Accumulation of Inflammatory Monocyte-Macrophages

(A) FACS plots show kinetics of Ly6C^hi CD11b⁺ inflammatory monocyte accumulation in the lungs.

(B) Percentage and total number of Ly6C^hi CD11b⁺ cells in the lungs.

(C) Phenotypic marker expression on inflammatory monocytes from the lungs of BALB/c mice at day 3 p.i.

(D) Cell surface levels of activation markers on lung IMMs at day 3 p.i.

(E) Total number of cytokine positive IMMs in the lungs determined following 7 hr ex vivo incubation in the presence of Golgi plug.

Data are derived from 2–3 independent experiments with 4 mice/group/experiment. Data in (B), (D), and (E) are represented as ±SEM. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. See also Figures S3 and S4.