Skip to main content
. 2016 Feb 10;19(2):181–193. doi: 10.1016/j.chom.2016.01.007

Figure 4.

Figure 4

Depletion of Inflammatory Monocytes Ameliorates SARS-CoV-Induced Lethal Disease

Survival and lung pathology were determined in young BALB/c mice treated with IMM-depleting and control antibodies.

(A and C) Weight curves and survival of SARS-CoV-infected BALB/c mice after control and MC21 (A) or anti-BST-2 (C) antibody treatment.

(B and D) Virus titers in the lungs at days 1 and 3 post control Ig and MC21 (B) or anti-BST-2 mAb (D) treatment.

(E) Histological changes in the lungs of naive, isotype-antibody-treated and IMM-depleted SARS-CoV-challenged BALB/c mice at day 5 p.i.

(F) Weight curves and survival of control and anti-TNF-α antibody-treated BALB/c mice.

(G) Survival of SARS-CoV-infected BALB/c mice after neutrophil depletion.

Data are representative of 2 independent experiments (4–5 mice/group/experiment). Data in (A)–(D) are represented as ±SEM. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001. See also Figures S2–S4.