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. 2016 Feb 13;8:11. doi: 10.1186/s13098-016-0128-6

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© Rezagholizadeh et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Effects of chicory extract on P65 DNA-binding activity. Liver tissue cell lysates with equal concentration of protein (20 µg; determined by Bradford) were used in this experiment. Optical density (OD) of samples was measured at 450 nm and OD changes was compared in all groups. P65 activity increased significantly in NIA/STZ and STZ groups compared with Control and CSE-control. Treatment with CSE significantly decreased P65 activity in CSE-NIA/STZ group compare with NIA/STZ group. Treatment with aspirin decreased it in Asp-STZ group when compared with STZ group. Metformin did not affect the P65 activity. Data are expressed as mean ± SD. *p < 0.0001; ^† p < 0.001; ^♦ p < 0.0001 versus Control