Fig. 3.

SIN3 isoform binding sites largely overlap. a Binding of SIN3 187HA and SIN3 220HA are depicted as standard genomic tracks on the integrated genomic viewer. Peaks were aligned to the built-in Drosophila melanogaster gene annotation track, shown in blue. Exons are shown in solid blue, introns as blue lines and arrows indicate the directionality of genes. SIN3 187HA and SIN3 220HA peaks as called by MACS2 are displayed in dark green and dark orange bars, respectively, below their enrichment tracks. Input tracks are shown in green for SIN3 187HA and orange for SIN3 220HA. All peaks shown are highly significant, P-value <1e-20. b Venn diagram showing the overlap of peaks between the SIN3 187HA and the SIN3 220HA ChIP-seq data. A minimum of 50 % overlap between peaks of the two SIN3 isoforms was considered